Sundar Uma, Adwani Sikandar
Neurology services, Internal Medicine, Lokmanya Tilak Municipal Medical College and Hospital, Sion, Mumbai, India.
Ann Indian Acad Neurol. 2010 Jan;13(1):42-6. doi: 10.4103/0972-2327.61276.
Vascular cognitive impairment, being the only treatable cause of dementia in the early stages, and having a diverse etiology, requires sensitive criteria for definition.
This study aimed to study cognitive functions at 3 months post-stroke, utilising the Mini mental scale examination (MMSE) and the Frontal assessment battery (FAB), and to correlate the same with subgroups of ischemic stroke.
164 patients were studied, 108 of these having multiple infarcts. Pure cortical infarcts were seen in 41 patients. At 3 months, 112/164 patients had MMSE more than 24, with no frontal executive dysfunction. MMSE score less than 24 was seen in 24 patients, all of them having FAB score below 10. Normal MMSE with impaired FAB was seen in 28 patients.
Impairment on either the MMSE or the FAB was thus seen in 31.7% patients (52/164), at 3 months after stroke. FAB impairment alone, with MMSE in normal range, was seen in 28/52 (53.8%) patients. Memory was significantly more commonly affected in muti-infarct strokes as compared to single infarcts. Frontal executive dysfunction was not significantly different when single and multiple infarcts, or cortical and subcortical infarcts, were compared.
血管性认知障碍是早期痴呆唯一可治疗的病因,且病因多样,需要敏感的定义标准。
本研究旨在利用简易精神状态检查表(MMSE)和额叶评估量表(FAB)研究卒中后3个月的认知功能,并将其与缺血性卒中的亚组进行关联。
共研究了164例患者,其中108例有多发梗死灶。41例患者出现单纯皮质梗死。3个月时,112/164例患者的MMSE评分高于24,无额叶执行功能障碍。24例患者的MMSE评分低于24,他们的FAB评分均低于10。28例患者MMSE正常但FAB受损。
因此,在卒中后3个月,31.7%(52/164)的患者出现MMSE或FAB受损。在52例受损患者中,28例(53.8%)仅FAB受损而MMSE在正常范围。与单发梗死相比,多发梗死性卒中时记忆受影响更为常见。比较单发和多发梗死,或皮质和皮质下梗死时,额叶执行功能障碍无显著差异。