Department of Biological Engineering, University of Missouri, 240 Agricultural Engineering Building, Columbia, MO 65211, USA.
Mol Neurobiol. 2010 Jun;41(2-3):138-48. doi: 10.1007/s12035-010-8121-9. Epub 2010 May 1.
Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-beta peptide (Abeta), a major component of senile plaques, has been shown to exert multiple toxic effects to neurons, astrocytes, glial cells, and brain endothelium. Oligomeric Abeta can disturb the structure and function of cell membranes and alter membrane mechanical properties, such as membrane fluidity and molecular order. Much of these effects are attributed to their capability to trigger oxidative stress and inflammation. In this review, we discuss the effects of Abeta on neuronal cells, astrocytes, and cerebral endothelial cells with special emphasis on cell membrane properties and cell functions.
阿尔茨海默病是一种慢性神经退行性疾病，其特征是神经元丧失、脑血管炎症以及脑实质和脑血管中老年斑的积累。淀粉样β肽（Abeta）是老年斑的主要成分，已被证明对神经元、星形胶质细胞、神经胶质细胞和脑内皮细胞具有多种毒性作用。寡聚 Abeta 可扰乱细胞膜的结构和功能，并改变膜的机械特性，如膜流动性和分子有序性。这些影响的大部分归因于它们引发氧化应激和炎症的能力。在这篇综述中，我们讨论了 Abeta 对神经元细胞、星形胶质细胞和脑内皮细胞的影响，特别强调了细胞膜特性和细胞功能。
