Bayat Mohammad, Javadieh Farshad, Dadpay Masoomeh
Cellular and Molecular Biology Research Center, Medical Faculty, Shahid Beheshti University, MC, PO Box 19395/4719, Tehran, 1985717443, Iran.
J Rehabil Res Dev. 2009;46(9):1135-42. doi: 10.1682/jrrd.2009.03.0035.
This study examined the influence of low-level laser therapy (LLLT) on the healing of a large osteochondral defect in rabbits.An osteochondral defect with 5 mm diameter was surgically induced in the right femoral patellar groove of 48 adult male rabbits. They were divided into a control and an experimental group. The rabbits were treated at 2, 4, 8, and 16 weeks after surgery, with six rabbits in each study period being tested at each biweekly period. The experimental group received LLLT with a helium-neon (He-Ne) laser (632.8 nm, 10 mW) of 148.4 J/cm(2) three times a week, and the control group received placebo LLLT with equipment switched off. The defects were examined macroscopically and microscopically. The results of the histological examination 2 weeks after surgery showed that the osteochondral healing of the control group was significantly accelerated compared with that of the experimental group. However, the osteochondral healing of the experimental group 4 weeks and 16 weeks after surgery showed that healing accelerated significantly compared with that of the control group. The conclusion was that LLLT with an He-Ne laser could not significantly accelerate healing of a large osteochondral defect in rabbits of the experimental group compared with that of the control group throughout the duration of the present study.
本研究探讨了低强度激光疗法（LLLT）对兔大骨软骨缺损愈合的影响。在48只成年雄性兔的右股骨髌沟手术制造一个直径5毫米的骨软骨缺损。将它们分为对照组和实验组。在术后2、4、8和16周对兔子进行治疗，每个研究时间段每两周测试6只兔子。实验组每周接受三次氦氖（He-Ne）激光（632.8纳米，10毫瓦）的低强度激光疗法，能量密度为148.4焦/平方厘米，对照组在设备关闭的情况下接受安慰剂低强度激光疗法。对缺损进行宏观和微观检查。术后2周的组织学检查结果显示，与实验组相比，对照组的骨软骨愈合明显加快。然而，术后4周和16周实验组的骨软骨愈合显示，与对照组相比愈合明显加快。结论是，在本研究的整个过程中，与对照组相比，氦氖激光低强度激光疗法不能显著加速实验组兔大骨软骨缺损的愈合。
