Santos Ely Almeida, Lira Rodrigo Pessoa Cavalcanti, Bicas Harley Edison Almaral, Gaete Maria Isabelle Lynch
University of Pernambuco, Recife, Brazil.
J Pediatr Ophthalmol Strabismus. 2011 Jan-Feb;48(1):38-44. doi: 10.3928/01913913-20100420-07. Epub 2010 Apr 22.
To study the action of botulinum toxin A on isometric contraction of the medial and lateral rectus muscles in esotropic or exotropic patients.
Isometric contraction in patients with strabismus (exotropic and esotropic) and in volunteers without strabismus was compared 30 days after the use of botulinum toxin A.
Findings show that this drug has changed the strength ratio between direct agonist and antagonist muscles. This has promoted the displacement of the point of equilibrium between muscle strengths toward the nasal direction in esotropic cases, toward the temporal direction in exotropic cases, and subsequent deviation of the eye toward its primary position. The average achieved correction was approximately 10 prism diopters in both groups of patients.
In both exotropia and esotropia, the average variations in the induced points of equilibrium related to injection of botulinum toxin A were similar. This means that the greatest percentage of corrections happened in cases of small deviations.
研究A型肉毒毒素对内斜视或外斜视患者内直肌和外直肌等长收缩的作用。
在使用A型肉毒毒素30天后，比较斜视患者（外斜视和内斜视）和无斜视志愿者的等长收缩情况。
研究结果表明，该药物改变了直接拮抗肌之间的力量比例。这促使内斜视患者肌肉力量平衡点向鼻侧移位，外斜视患者向颞侧移位，随后眼球向其初始位置偏斜。两组患者平均获得的矫正量约为10棱镜度。
在外斜视和内斜视中，与注射A型肉毒毒素相关的诱导平衡点平均变化相似。这意味着在小度数偏斜的病例中矫正比例最高。
