Genentech BioOncology, 1 DNA Way, South San Francisco, California 94080, USA.
Clin Cancer Res. 2010 Jul 1;16(13):3335-9. doi: 10.1158/1078-0432.CCR-09-2570. Epub 2010 May 3.
The hedgehog (Hh) signaling pathway plays an important role in embryogenesis across multiple species. Its activity is reduced or absent in adult organisms. However, activation of the pathway has been shown to be a factor in the development of a number of human malignancies and inhibition of the pathway is being investigated as a potential treatment for multiple cancers. The most extensively investigated and best characterized is basal cell carcinoma (BCC), which occurs in both an inherited form (basal cell nevus syndrome or Gorlin's syndrome) and a sporadic form. Sporadic BCCs are the most common human malignancy. There is recent data available on the use of a small molecule inhibitor of the pathway in BCC.
刺猬（Hh）信号通路在多个物种的胚胎发生中起着重要作用。它在成年生物体中的活性降低或缺失。然而，该通路的激活已被证明是许多人类恶性肿瘤发展的一个因素，并且抑制该通路被作为多种癌症的潜在治疗方法正在进行研究。研究最多、特征最明确的是基底细胞癌（BCC），它既有遗传性形式（基底细胞痣综合征或 Gorlin 综合征）也有散发性形式。散发性 BCC 是最常见的人类恶性肿瘤。目前有关于该通路的小分子抑制剂在 BCC 中的应用的最新数据。
