Department of Dermatology, Venereology, and Leprology, Government Medical College & Associated Hospitals, University of Jammu, Jammu, J&K, 180001, India.
Adv Exp Med Biol. 2022;1367:397-409. doi: 10.1007/978-3-030-92616-8_16.
Non-melanoma skin cancer (NMSC) is the most common malignancy seen in Caucasians and includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The incidence of NMSC is showing an increasing trend which is attributed to the increased use of sunbeds, recreational sun exposure, aging population, and partly to improved screening and reporting. Ultraviolet (UV) radiation plays the most crucial role in the pathogenesis of both BCC and SCC by inducing DNA damage and mutagenic photoproducts. Other risk factors are fair skin, old age, genetic predisposition, immunosuppression, ionizing radiation, organic chemicals, and HPV infection. The role of genomic instability, genetic mutations/aberrations, and host immunity has been fairly illustrated in several studies. This chapter aims to discuss these aspects of NMSC in detail.
非黑色素瘤皮肤癌（NMSC）是白种人最常见的恶性肿瘤，包括基底细胞癌（BCC）和鳞状细胞癌（SCC）。NMSC 的发病率呈上升趋势，这归因于晒床、休闲日光暴露、人口老龄化的增加，部分原因是筛查和报告的改善。紫外线（UV）辐射通过诱导 DNA 损伤和致突变光产物，在 BCC 和 SCC 的发病机制中起着最关键的作用。其他危险因素包括皮肤白皙、年龄较大、遗传易感性、免疫抑制、电离辐射、有机化学物质和 HPV 感染。基因组不稳定性、遗传突变/异常和宿主免疫在几项研究中得到了充分的说明。本章旨在详细讨论 NMSC 的这些方面。
