一例与类风湿关节炎相关的正常压力脑积水。

A case of normal-pressure hydrocephalus associated with rheumatoid arthritis.

机构信息

Centro Medicina dell'Invecchiamento, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Largo F. Vito 1, Rome, Italy.

出版信息

Aging Clin Exp Res. 2010 Apr;22(2):189-91. doi: 10.1007/BF03324795.

DOI:10.1007/BF03324795

PMID:20440105

Abstract

Rheumatoid arthritis may cause central nervous system complications by means of various mechanisms. We describe the case of a patient with a new diagnosis of rheumatoid arthritis (RA) complicated by normal-pressure hydrocephalus. After treatment with prednisone, the patient improved remarkably as regards mental status, urinary control and gait. We suggest that normal-pressure hydrocephalus may occur as an extra-articular manifestation of RA, caused by a pathogenic inflammatory mechanism. We analyse previous case reports describing a relationship between RA and normal-pressure hydrocephalus, and discuss potential mechanisms underlying this association.

摘要

类风湿关节炎可能通过多种机制引起中枢神经系统并发症。我们描述了一例新诊断的类风湿关节炎（RA）并发正常压力脑积水的病例。经泼尼松治疗后，患者的精神状态、尿控和步态均显著改善。我们认为，正常压力脑积水可能是 RA 的关节外表现之一，由致病炎症机制引起。我们分析了既往描述 RA 与正常压力脑积水之间关系的病例报告，并讨论了这种关联的潜在机制。