Evans S
Saint Joseph's Medical Center, South Bend, IN 46637.
Cancer Nurs. 1991 Apr;14(2):91-7.
Renal tubule damage as a result of the nephrotoxic effects of cisplatin is a well-documented effect of cisplatin administration. This damage results in electrolyte imbalances through electrolyte wasting and electrolyte reabsorption failure in the renal tubule. Electrolytes most commonly affected are magnesium, calcium, and potassium. Other indicators of renal cell damage are elevations in blood urea nitrogen and serum creatinine and a decrease in creatinine clearance levels. Individuals with marginal renal function or those who have had multiple doses of cisplatin or other nephrotoxic drugs are at increased risk for developing nephrotoxicity. Early assessment of risk factors and the implementing and evaluating of interventions to facilitate prevention of nephrotoxicity will presumably minimize the incidence and degree of renal damage.
顺铂的肾毒性作用导致的肾小管损伤是顺铂给药的一个有充分文献记载的效应。这种损伤通过肾小管中的电解质流失和电解质重吸收失败导致电解质失衡。最常受影响的电解质是镁、钙和钾。肾细胞损伤的其他指标是血尿素氮和血清肌酐升高以及肌酐清除率水平降低。肾功能处于临界状态的个体或接受过多次顺铂或其他肾毒性药物治疗的个体发生肾毒性的风险增加。对危险因素进行早期评估以及实施和评估有助于预防肾毒性的干预措施，大概可以将肾损伤的发生率和程度降至最低。
