Campeau L
Cardiovasc Clin. 1991;21(2):123-33.
Atherosclerosis frequently develops in SVGs during the first 10 years. This process appears related to coronary risk factors. Several studies have found an association between hyperlipidemia and atherosclerosis documented at pathology. Late changes attributed to atherosclerosis that were observed at angiography were also significantly related to elevated serum levels of total cholesterol and triglycerides. They also were found in association with diabetes, systemic hypertension, and smoking in some studies. Several clinical studies have documented an association of one or several coronary risk factors with postoperative clinical events, including recurrence of angina, myocardial infarction, heart failure, reoperation because of clinical deterioration, and survival. These factors have been shown to act alone or in combination. The most important is an abnormal lipid profile and diabetes. Smoking and hypertension were seldom found to be significant predictors when considered separately, but appear to play an important role in association with the others. Control of coronary risk factors, particularly hyperlipidemia and smoking, seems mandatory in order to prevent SVG atherosclerosis and progression of the disease in the native coronary arteries.
在头10年里，静脉桥血管常发生动脉粥样硬化。这一过程似乎与冠心病危险因素有关。多项研究发现高脂血症与病理学上记录的动脉粥样硬化之间存在关联。血管造影术中观察到的归因于动脉粥样硬化的晚期变化也与血清总胆固醇和甘油三酯水平升高显著相关。在一些研究中，它们还与糖尿病、系统性高血压和吸烟有关。多项临床研究记录了一种或几种冠心病危险因素与术后临床事件之间的关联，这些事件包括心绞痛复发、心肌梗死、心力衰竭、因临床病情恶化而再次手术以及生存率。这些因素已被证明单独或联合起作用。最重要的是脂质异常和糖尿病。单独考虑时，吸烟和高血压很少被发现是显著的预测因素，但似乎与其他因素联合时发挥重要作用。为预防静脉桥血管动脉粥样硬化及疾病在自身冠状动脉中的进展，控制冠心病危险因素，尤其是高脂血症和吸烟，似乎是必不可少的。
