Department of Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, 30332, USA.
Adv Drug Deliv Rev. 2010 Dec 30;62(15):1468-78. doi: 10.1016/j.addr.2010.04.007. Epub 2010 May 2.
Biomaterials derived from protein-based block copolymers are increasingly investigated for potential application in medicine. In particular, recombinant elastin block copolymers provide significant opportunities to modulate material microstructure and can be processed in various forms, including particles, films, gels, and fiber networks. As a consequence, biological and mechanical responses of elastin-based biomaterials are tunable through precise control of block size and amino acid sequence. In this review, the synthesis of a set of elastin-mimetic triblock copolymers and their diverse processing methods for generating material platforms currently applied in medicine will be discussed.
基于蛋白质的嵌段共聚物衍生的生物材料越来越多地被用于医学应用的研究。特别是,重组弹性蛋白嵌段共聚物为调节材料微观结构提供了重要机会,并且可以以各种形式进行加工,包括颗粒、薄膜、凝胶和纤维网络。因此,基于弹性蛋白的生物材料的生物学和机械响应可以通过精确控制嵌段大小和氨基酸序列来调节。在这篇综述中,将讨论一组弹性蛋白模拟的三嵌段共聚物的合成及其用于生成当前应用于医学的材料平台的各种加工方法。