Taylor F B, Chang A, Ruf W, Morrissey J H, Hinshaw L, Catlett R, Blick K, Edgington T S
Oklahoma Medical Research Foundation, Oklahoma City.
Circ Shock. 1991 Mar;33(3):127-34.
Gram-negative bacteremia poses a major health problem, causing one-half of cases of lethal septic shock acquired during hospitalization. Bacterial lipopolysaccharide (LPS) and the inflammatory cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), have been shown to be essential mediators of septic shock. Among the effects of these mediators is a coagulopathy that may be triggered by induced expression of tissue factor (TF) on macrophages and endothelial cells. We now report that 500 micrograms/kg of either immunoglobulin G (IgG) or Fab fragments of a monoclonal antibody against TF administered to baboons as a pretreatment attenuates the coagulopathy and protects against LD100 Escherichia coli. This study provides direct evidence of an essential effector role for TF in septic shock.
革兰氏阴性菌血症是一个重大的健康问题，导致住院期间获得的致死性感染性休克病例中有一半。细菌脂多糖（LPS）以及炎性细胞因子，肿瘤坏死因子（TNF）和白细胞介素-1（IL-1），已被证明是感染性休克的重要介质。这些介质的作用之一是凝血病，它可能由巨噬细胞和内皮细胞上组织因子（TF）的诱导表达引发。我们现在报告，以500微克/千克的免疫球蛋白G（IgG）或抗TF单克隆抗体的Fab片段预处理狒狒，可减轻凝血病并预防LD100大肠杆菌感染。这项研究提供了TF在感染性休克中起重要效应作用的直接证据。
