Clinical Emergency County Hospital "Sf. Ap. Andrei", 800578 Galați, Romania.
Faculty of Medicine and Pharmacy, Dunarea de Jos University, 800008 Galați, Romania.
Medicina (Kaunas). 2021 Aug 25;57(9):872. doi: 10.3390/medicina57090872.
Urosepsis is a very serious condition with a high mortality rate. The immune response is in the center of pathophysiology. The therapeutic management of these patients includes surgical treatment of the source of infection, antibiotic therapy and life support. The management of this pathology is multidisciplinary and requires good collaboration between the urology, intensive care, imaging and laboratory medicine departments. An imbalance of pro and anti-inflammatory cytokines produced during sepsis plays an important role in pathogenesis. The study of cytokines in sepsis has important implications for understanding pathophysiology and for development of other therapeutic solutions. If not treated adequately, urosepsis may lead to serious septic complications and organ sequelae, even to a lethal outcome.
尿脓毒症是一种非常严重的疾病，死亡率很高。免疫反应是发病机制的核心。这些患者的治疗管理包括感染源的手术治疗、抗生素治疗和生命支持。这种病理的管理是多学科的，需要泌尿科、重症监护、影像学和实验室医学等部门之间的良好协作。在脓毒症期间产生的促炎和抗炎细胞因子的失衡在发病机制中起着重要作用。对脓毒症中细胞因子的研究对理解发病机制和开发其他治疗方法具有重要意义。如果治疗不充分，尿脓毒症可能导致严重的脓毒症并发症和器官后遗症，甚至导致致命后果。
