Ansari Reza, Sohrabi Sahand, Ghanaie Omid, Amjadi Hiva, Merat Shahin, Vahedi Homayoun, Khatibian Morteza
Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Iran.
Indian J Gastroenterol. 2010 Mar;29(2):66-8. doi: 10.1007/s12664-010-0015-2. Epub 2010 May 5.
BACKGROUND/AIM: Functional constipation (FC) and constipation-predominant IBS (C-IBS) are two main subtypes of constipation. Using radio-opaque markers is an easy and cost effective method to measure colonic transit time (CTT). We designed this study to compare the CTT between these two groups of constipated patients.
Patients with chronic constipation of no organic etiology were classified as having FC or C-IBS according to the Rome II criteria. All patients ingested 10 radio opaque markers daily for six days. A plain abdominal X-ray was taken on the seventh day. To calculate the total and segmental colonic transit time in hours, number of markers in right and left colonic and rectosigmoid area were counted and multiplied by 2.4. The mean total and segmental colonic transit time were compared between the two groups.
A total of 100 patients (50 FC and 50 C-IBS) were enrolled. The mean (SD) total CTT was not significantly different between FC patients (52.2 [35.5] h) and C-IBS patients (41.2 [31.6] h; p = 0.10). The mean rectosigmoid transit time was significantly slower in FC patients (19.9 [15.5] h) compared to C-IBS patients (11.9 [10.6] h; p = 0.003).
Rectosigmoid transit time in FC patients is slower than in C-IBS patients.
背景/目的：功能性便秘（FC）和以便秘为主型肠易激综合征（C-IBS）是便秘的两种主要亚型。使用不透X线标志物是一种测量结肠传输时间（CTT）的简便且经济有效的方法。我们设计本研究以比较这两组便秘患者的结肠传输时间。
无器质性病因的慢性便秘患者根据罗马II标准分为功能性便秘或便秘为主型肠易激综合征。所有患者连续6天每天摄入10个不透X线标志物。在第7天进行腹部平片检查。为计算以小时为单位的结肠总传输时间和节段传输时间，对右半结肠、左半结肠及直肠乙状结肠区域的标志物数量进行计数并乘以2.4。比较两组患者结肠总传输时间和节段传输时间的平均值。
共纳入100例患者（50例功能性便秘和50例便秘为主型肠易激综合征）。功能性便秘患者的平均（标准差）结肠总传输时间（52.2 [35.5]小时）与便秘为主型肠易激综合征患者（41.2 [31.6]小时；p = 0.10）相比无显著差异。与便秘为主型肠易激综合征患者（11.9 [10.6]小时；p = 0.003）相比，功能性便秘患者的直肠乙状结肠传输时间明显较慢。
功能性便秘患者的直肠乙状结肠传输时间比便秘为主型肠易激综合征患者慢。
