Divisions of Cardiology, Nutrition and Preventive Medicine, Department of Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA.
Obes Surg. 2010 Jul;20(7):949-52. doi: 10.1007/s11695-010-0178-z.
Obesity as well as bariatric surgery may increase the risk for vitamin D deficiency. We retrospectively compared vitamin D levels in obese patients (n = 123) prior to bariatric surgery and 1 year postoperatively. We also evaluated parathyroid hormone levels (PTH) 1 year after surgery. A higher percentage of patients had baseline vitamin D deficiency (86%), defined as 25-hydroxy vitamin D <32 ng/mL, compared with the 1-year (post-surgical) levels, (70%; p < 0.001). Body mass index (BMI) inversely correlated with vitamin D deficiency at baseline (r = -0.3, p = 0.06) and at the postoperative follow-up (r = -0.2, p = 0.013). One third of the postoperative population had secondary hyperparathyroidism, defined by a serum PTH level >62 pg/mL; however, postoperative PTH and vitamin D levels were unrelated (r = -0.001, p = 0.994). Pre- and postoperative vitamin D levels were inversely correlated with BMI. Secondary hyperparathyroidism was observed in 33% of patients postoperatively; however, this did not correlate with vitamin D.
肥胖以及减重手术可能会增加维生素 D 缺乏的风险。我们回顾性比较了肥胖患者（n=123）在减重手术前和术后 1 年的维生素 D 水平。我们还评估了术后 1 年甲状旁腺激素（PTH）水平。与术后 1 年（手术）相比，更多患者存在基线维生素 D 缺乏（定义为 25-羟维生素 D <32ng/mL）（86%对 70%；p<0.001）。基线时（r=-0.3，p=0.06）和术后随访时（r=-0.2，p=0.013），BMI 与维生素 D 缺乏呈负相关。三分之一的术后人群存在血清 PTH 水平>62pg/mL 的继发性甲状旁腺功能亢进症；然而，术后 PTH 和维生素 D 水平无相关性（r=-0.001，p=0.994）。术前和术后维生素 D 水平与 BMI 呈负相关。术后 33%的患者出现继发性甲状旁腺功能亢进症；然而，这与维生素 D 无关。
