血管内皮生长因子 mRNA 在人子宫肌瘤中的表达。

Expression of vascular endothelial growth factor mRNA in human leiomyomas.

机构信息

Department and Clinic of Obstetrics, Gynecology and Oncology, II Faculty, Medical University of Warsaw, Warsaw, Poland.

出版信息

Gynecol Endocrinol. 2010 Jun;26(6):451-5. doi: 10.3109/09513591003632159.

DOI:10.3109/09513591003632159

PMID:20443739

Abstract

AIM

Growth factors play a major role in the pathogenesis of uterine myomas. The aim of this study was to evaluate vascular endothelial growth factor (VEGF) mRNA expression during leiomyoma growth at different phases of the menstrual cycle with RT-PCR.

METHOD

We studied 56 patients: 43 with myomas, 13 with healthy myometriums. In patients with myomas (secretory phase), VEGF expression was 2.82 times higher than in control patients (p < 0.05). In patients with myomas (phase I), VEGF expression was 2.53 times higher (p < 0.05) than in control patients. For all patients with myomas, those who were in menopause had 1.52 times higher VEGF expression than those who menstruated. For patients with healthy myometriums, those who were in menopause had 1.97 times higher VEGF expression than those who menstruated. A comparison of all the patients in menopause revealed that VEGF expression was 2.03-fold higher in those with myomas than in those with healthy myometriums.

CONCLUSION

We observed the highest VEGF mRNA expression in women with myomas who were in menopause. Among menstruating patients, VEGF expression was significantly higher in those with myomas compared to those with a healthy myometrium. This suggested that VEGF may play a significant role in the pathogenesis of uterine myomas.

摘要

目的

生长因子在子宫肌瘤的发病机制中起着重要作用。本研究旨在通过 RT-PCR 评估血管内皮生长因子（VEGF）mRNA 在子宫肌瘤生长不同阶段的表达。

方法

我们研究了 56 名患者：43 名患有子宫肌瘤，13 名患有健康的子宫肌层。在患有子宫肌瘤的患者（分泌期）中，VEGF 的表达比对照组高 2.82 倍（p < 0.05）。在患有子宫肌瘤的患者（I 期）中，VEGF 的表达比对照组高 2.53 倍（p < 0.05）。对于所有患有子宫肌瘤的患者，绝经后的患者 VEGF 表达比月经期的患者高 1.52 倍。对于患有健康子宫肌层的患者，绝经后的患者 VEGF 表达比月经期的患者高 1.97 倍。对所有绝经后患者进行比较，发现患有子宫肌瘤的患者的 VEGF 表达比患有健康子宫肌层的患者高 2.03 倍。