Sox 蛋白在黑素细胞发育和黑色素瘤中的作用。
Sox proteins in melanocyte development and melanoma.
机构信息
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Pigment Cell Melanoma Res. 2010 Aug;23(4):496-513. doi: 10.1111/j.1755-148X.2010.00711.x. Epub 2010 Apr 22.
Over 10 years have passed since the first Sox gene was implicated in melanocyte development. Since then, we have discovered that SOX5, SOX9, SOX10 and SOX18 all participate as transcription factors that affect key melanocytic genes in both regulatory and modulatory fashions. Both SOX9 and SOX10 play major roles in the establishment and normal function of the melanocyte; SOX10 has been shown to heavily influence melanocyte development and SOX9 has been implicated in melanogenesis in the adult. Despite these advances, the precise cellular and molecular details of how these SOX proteins are regulated and interact during all stages of the melanocyte life cycle remain unknown. Improper regulation of SOX9 or SOX10 is also associated with cancerous transformation, and thus understanding the normal function of SOX proteins in the melanocyte will be key to revealing how these proteins contribute to melanoma.
自第一个 Sox 基因被牵涉到黑素细胞发育以来，已经过去了 10 多年。从那时起，我们发现 SOX5、SOX9、SOX10 和 SOX18 都作为转录因子参与其中，以调节和修饰的方式影响关键的黑素细胞基因。SOX9 和 SOX10 都在黑素细胞的建立和正常功能中发挥主要作用；SOX10 已被证明对黑素细胞的发育有很大影响，而 SOX9 则被牵连到成人体内的黑素生成。尽管取得了这些进展，但这些 Sox 蛋白在黑素细胞生命周期的所有阶段是如何被调控和相互作用的，其确切的细胞和分子细节仍不清楚。SOX9 或 SOX10 的调控不当也与癌变有关，因此了解 Sox 蛋白在黑素细胞中的正常功能将是揭示这些蛋白如何促进黑色素瘤的关键。
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