Meyn Hannes, Kraemer Markus, de Greiff Armin, Diehl Rolf R
Department of Neurology, Alfried Krupp von Bohlen und Halbach Hospital, Alfried-Krupp-Strasse 21, 45117 Essen, Germany.
Clin Neurol Neurosurg. 2010 Jul;112(6):490-5. doi: 10.1016/j.clineuro.2010.04.003. Epub 2010 May 4.
Previous fMRI studies on activation of working memory in multiple sclerosis (MS) patients presented heterogeneous results. Patients were reported to have altered brain activation patterns either in typical working memory circuits or in other brain regions even if they did not have any cognitive impairment according to the test batteries. We hypothesized that brain activation patterns in patients at a very early stage of the disease at very low EDSS-Score would not differ from healthy subjects.
We examined 13 patients at an early stage of MS matched with 13 healthy controls with a detailed psychometric test battery and an fMRI working memory paradigm.
Patients and healthy controls did not differ in psychometric test batteries. In both groups those cortex areas typically involved in working memory processes like dorso-lateral prefrontal (DLPFC), ventro-lateral-prefrontal (VLPFC), fronto-medial and parietal cortex areas (Brodmann 6, 7, 8, 9, 10, 32, 40, 45, 46, 47) were equally activated.
In contrast to former studies we found no differences in activation patterns in the fMRI scanning measuring working memory tasks between psychometrically tested homogenous groups of patients in early stages of MS and control subjects.
先前关于多发性硬化症（MS）患者工作记忆激活的功能磁共振成像（fMRI）研究结果不一。据报道，即使根据测试组合患者没有任何认知障碍，他们在典型的工作记忆回路或其他脑区的脑激活模式也会发生改变。我们假设疾病极早期且扩展残疾状态量表（EDSS）评分极低的患者的脑激活模式与健康受试者没有差异。
我们使用详细的心理测量测试组合和fMRI工作记忆范式，对13例MS早期患者和13例健康对照进行了检查。
患者和健康对照在心理测量测试组合方面没有差异。在两组中，通常参与工作记忆过程的皮质区域，如背外侧前额叶（DLPFC）、腹外侧前额叶（VLPFC）、额内侧和顶叶皮质区域（布罗德曼区6、7、8、9、10、32、40、45、46、47）的激活程度相同。
与先前的研究不同，我们发现在心理测量测试的早期MS同质患者组和对照受试者之间，在测量工作记忆任务的fMRI扫描中，激活模式没有差异。
