Forn C, Barros-Loscertales A, Escudero J, Belloch V, Campos S, Parcet M A, Avila C
Dept. Psicologia, Campus Riu Sec, Fac. Ciencies Humanes i Socials, Universitat Jaume I, e-12071 Castelló, Spain.
Neuroimage. 2006 Jun;31(2):686-91. doi: 10.1016/j.neuroimage.2005.12.030. Epub 2006 Feb 8.
Cortical reorganization in multiple sclerosis (MS) is defined as a compensatory mechanism which requires MS patients to overactivate specific brain areas in order to perform the task as controls. To investigate this process with the Paced Auditory Serial Addition Test (PASAT) task, we selected 15 MS patients who performed the PASAT task within-normal limits and 10 healthy controls. Once selected, we used functional magnetic resonance imaging (fMRI) to investigate brain areas involved in PASAT performance in both groups. Results showed that the task activated the left frontal (BA6 and 9) and parietal cortex (BA7 and 40) in both groups, but MS patients showed a stronger activation in the left prefrontal cortex (BA9, 44 and 45) when compared with controls. These results confirmed those obtained post hoc by Audoin et al. [Audoin, B., Ibarrola, D., Ranjeva, J.P., Confort-Gouny, S., Malikova, I., Ali-Chérif, A.M., Pelletier, J., Cozzone, P., et al., 2003. Compensatory cortical activation observed by fMRI during cognitive task at the earliest stage of MS. Hum. Brain Mapp. 20, 51-58], and we interpreted this as showing true cortical reorganization.
多发性硬化症（MS）中的皮质重组被定义为一种补偿机制，这要求MS患者过度激活特定脑区，以便像对照组一样执行任务。为了使用听觉序列加法测验（PASAT）任务来研究这一过程，我们选取了15名在正常范围内完成PASAT任务的MS患者以及10名健康对照者。一经选定，我们使用功能磁共振成像（fMRI）来研究两组中参与PASAT任务执行的脑区。结果显示，该任务在两组中均激活了左侧额叶（BA6和9区）和顶叶皮质（BA7和40区），但与对照组相比，MS患者在左侧前额叶皮质（BA9、44和45区）表现出更强的激活。这些结果证实了奥多安等人事后获得的结果[奥多安，B.，伊巴罗拉，D.，兰热瓦，J.P.，孔福尔-古尼，S.，马利科娃，I.，阿里-谢里夫，A.M.，佩尔蒂埃，J.，科佐内，P.等，2003年。MS最早阶段认知任务期间通过fMRI观察到的代偿性皮质激活。《人类脑图谱》20，51 - 58页]，我们将此解释为显示了真正的皮质重组。
