Habek Mario, Hojsak Iva, Brinar Vesna V
School of Medicine, University of Zagreb, Department of Neurology, Zagreb, Croatia.
Clin Neurol Neurosurg. 2010 Sep;112(7):616-20. doi: 10.1016/j.clineuro.2010.03.029. Epub 2010 May 4.
Multiple sclerosis (MS) is a chronic idiopathic inflammatory demyelinating disease that causes neurological disability in young adults. Etiology of the disease is still unknown, but it has an immune-mediated basis and occurs in genetically susceptible individuals. Nutritional status and dietary habits in MS patients have not been extensively studied or reported, however individual findings suggest that many patients suffer from various forms of malnutrition. In patients with MS, malnutrition has been associated with impairment of the immune system; it affects mental function, respiratory muscle strength and increases a risk of specific nutrient deficiencies. These findings emphasize the need for nutritional support in MS patients. On the other hand, several nutritional compounds have been investigated as a possible treatment in MS, mostly polyunsaturated fatty acids and vitamin D, however their role in the treatment is yet to be confirmed. The aim of this review is to present data on the role of nutritional assessment and treatment in patients with MS.
多发性硬化症（MS）是一种慢性特发性炎性脱髓鞘疾病，可导致年轻人出现神经功能障碍。该疾病的病因尚不清楚，但具有免疫介导的基础，且发生于遗传易感性个体中。MS患者的营养状况和饮食习惯尚未得到广泛研究或报道，不过个别研究结果表明，许多患者存在各种形式的营养不良。在MS患者中，营养不良与免疫系统受损有关；它会影响心理功能、呼吸肌力量，并增加特定营养素缺乏的风险。这些发现强调了MS患者需要营养支持。另一方面，几种营养化合物已被研究作为MS的一种可能治疗方法，主要是多不饱和脂肪酸和维生素D，然而它们在治疗中的作用尚未得到证实。本综述的目的是介绍有关营养评估和治疗在MS患者中的作用的数据。
