Department of Basic Sciences, Catholic University of Valencia San Vicente Mártir, 46900 Torrent, Spain.
Doctoral Degree School, Catholic University of Valencia San Vicente Mártir, 46001 Valencia, Spain.
Nutrients. 2020 Mar 11;12(3):744. doi: 10.3390/nu12030744.
Multiple sclerosis (MS) is a chronic neurodegenerative disease of an inflammatory, demyelinating and autoimmune nature. Diets with a high caloric density could be especially relevant in terms of the pathogenesis related to an increase in adipose tissue that is metabolically active and releases mediators, which can induce systemic inflammation and an increased oxidation state. The aim of this study was to analyse the eating habits related to calorie intake and their impact on abdominal obesity associated with anthropometric variables, the activity of the oxidation marker paraoxonase 1 (PON1), and interleukin 6 (IL-6) levelsin MS patients.
An analytical and quantitative observational study was conducted with a population of 57 MS patients. The dietary-nutritional anamnesis was gained through the Food Frequency Questionnaire and a food diary. Diet and eating habits have been analysed through the Easy Diet-Programa de gestión de la consulta® software. Anthropometric measurements were taken in order to determine the presence of abdominal obesity. In addition, PON1 was quantified in serum by means of automated spectrophotometric assays and IL-6 was quantified using the ELISA technique.
A normal calorie intake was determined for women, yet a slightly lower intake was observed in men. Carbohydrate consumption was below what was established, and protein and lipids were over, in both cases. Furthermore, most patients had abdominal obesity, with significantly higher body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), fat percentage and IL-6 levels. IL-6 is greatly correlated with waist circumference and WHtR.
MS patients' nutrient intake shows an imbalance between macronutrients. This seems to favour the abdominal obesity associated with high values of proinflammatory IL-6 that is not correlated with a lower activity of PON1.
多发性硬化症（MS）是一种慢性神经退行性疾病，具有炎症、脱髓鞘和自身免疫性质。高卡路里密度的饮食可能与与脂肪组织代谢活跃和释放介质相关的发病机制特别相关，这些介质可以诱导全身炎症和氧化状态增加。本研究的目的是分析与卡路里摄入量相关的饮食习惯及其对与人体测量学变量相关的腹部肥胖的影响，氧化标志物对氧磷酶 1（PON1）的活性以及 MS 患者的白细胞介素 6（IL-6）水平。
对 57 名 MS 患者进行了分析性和定量观察性研究。通过食物频率问卷和食物日记获得饮食-营养病史。通过 Easy Diet-Programa de gestión de la consulta®软件分析饮食和饮食习惯。进行了人体测量学测量，以确定是否存在腹部肥胖。此外，通过自动分光光度法测定血清中的 PON1，通过 ELISA 技术测定 IL-6。
确定了女性的正常卡路里摄入量，但男性的摄入量略低。碳水化合物的摄入量低于规定值，而蛋白质和脂肪的摄入量则高于规定值。此外，大多数患者存在腹部肥胖，体重指数（BMI）、腰臀比（WHR）、腰高比（WHtR）、脂肪百分比和 IL-6 水平明显较高。IL-6 与腰围和 WHtR 高度相关。
MS 患者的营养素摄入显示出宏量营养素之间的不平衡。这似乎有利于与高值促炎 IL-6 相关的腹部肥胖，而与 PON1 活性降低无关。
