自杀和非致命性自杀行为的遗传影响：双胞胎研究结果。
Genetic influences on suicide and nonfatal suicidal behavior: twin study findings.
机构信息
Department of Medical Epidemiology and Biostatistics, Box 281, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
出版信息
Eur Psychiatry. 2010 Jun;25(5):264-7. doi: 10.1016/j.eurpsy.2009.12.008. Epub 2010 May 4.
Abstract
It has been well established that suicidal behavior is familial. Twin studies provide a unique opportunity to distinguish genetic effects from other familial influences. Consistent with findings from previous twin studies, including case series and selected samples, data from the population-based Swedish Twin Registry clearly demonstrate the importance of genetic influences on suicide. Twin studies of suicidal ideation and suicide attempts also implicate genetic influences, even when accounting for the effects of psychopathology. Future work is needed to evaluate the possibility of age and gender differences in heritability of suicide and nonfatal suicidal behavior.
摘要
已经证实自杀行为具有家族性。双胞胎研究为区分遗传效应与其他家族影响提供了独特的机会。与之前包括病例系列和选择性样本在内的双胞胎研究的发现一致，基于人群的瑞典双胞胎登记处的数据清楚地表明遗传对自杀的重要影响。对自杀意念和自杀企图的双胞胎研究也表明遗传有影响，即使考虑到精神病理学的影响也是如此。需要进一步的研究来评估遗传对自杀和非致命性自杀行为的可能性的年龄和性别差异。
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