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p63 在皮肤发育和外胚层发育不良中的作用。

p63 in skin development and ectodermal dysplasias.

机构信息

Department of Dermatology, Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, Colorado 80045, USA.

出版信息

J Invest Dermatol. 2010 Oct;130(10):2352-8. doi: 10.1038/jid.2010.119. Epub 2010 May 6.

DOI:10.1038/jid.2010.119
PMID:20445549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2919658/
Abstract

The transcription factor p63 is critically important for skin development and maintenance. Processes that require p63 include epidermal lineage commitment, epidermal differentiation, cell adhesion, and basement membrane formation. Not surprisingly, alterations in the p63 pathway underlie a subset of ectodermal dysplasias, developmental syndromes in which the skin and skin appendages do not develop normally. This review summarizes the current understanding of the role of p63 in normal development and ectodermal dysplasias.

摘要

转录因子 p63 对皮肤的发育和维持至关重要。需要 p63 的过程包括表皮谱系的承诺、表皮分化、细胞黏附和基底膜的形成。毫不奇怪，p63 途径的改变是外胚层发育不良的一部分，这些发育综合征中皮肤和皮肤附属物不能正常发育。这篇综述总结了目前对 p63 在正常发育和外胚层发育不良中的作用的理解。

相似文献

[1]
p63 in skin development and ectodermal dysplasias.

J Invest Dermatol. 2010-5-6

[2]
IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias.

J Invest Dermatol. 2009-1

[3]
Improvement of epidermal covering on AEC patients with severe skin erosions by PRIMA-1/APR-246.

Cell Death Dis. 2020-1-16

[4]
A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias.

J Clin Invest. 2010-4-26

[5]
Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.

Development. 2007-1

[6]
Etiology and pathogenesis of ectodermal dysplasias.

Am J Med Genet A. 2014-10

[7]
Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology.

Br J Dermatol. 2012-5-14

[8]
Claudin-1 is a p63 target gene with a crucial role in epithelial development.

PLoS One. 2008-7-23

[9]
Ectodermal dysplasias.

Am J Med Genet C Semin Med Genet. 2004-11-15

[10]
Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.

Proc Natl Acad Sci U S A. 2013-1-25

引用本文的文献

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The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin.

PLoS One. 2025-1-3

[2]
Hay-Wells syndrome: the challenges of a nine-year follow-up.

An Bras Dermatol. 2024

[3]
ΔNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis.

PLoS One. 2024

[4]
Effects of TP63 mutations on keratinocyte adhesion and migration.

Exp Dermatol. 2023-9

[5]
Innovative Therapeutic Approaches for the Treatment of the Ocular Morbidities in Patients with EEC Syndrome.

Cells. 2023-2-2

[6]
Molecular Pathway-Based Classification of Ectodermal Dysplasias: First Five-Yearly Update.

Genes (Basel). 2022-12-10

[7]
A Maverick Review of Common Stem/Progenitor Markers in Lung Development.

Stem Cell Rev Rep. 2022-12

[8]
CDK12 Is Necessary to Promote Epidermal Differentiation Through Transcription Elongation.

Stem Cells. 2022-4-29

[9]
Transcriptomic and Functional Evidence Show Similarities between Human Amniotic Epithelial Stem Cells and Keratinocytes.

Cells. 2021-12-27

[10]
Mosaic variant and associated ectodermal dysplasia features.

JAAD Case Rep. 2021-9-28

本文引用的文献

[1]
p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes.

Cancer Res. 2009-11-15

[2]
Downregulation of DeltaNp63alpha in keratinocytes by p14ARF-mediated SUMO-conjugation and degradation.

Cell Cycle. 2009-12-1

[3]
p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.

J Biol Chem. 2009-10-30

[4]
Identification and functional characterization of two new transcriptional variants of the human p63 gene.

Nucleic Acids Res. 2009-10

[5]
Dermatologic findings of ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome.

Am J Med Genet A. 2009-9

[6]
DeltaNp63 knockdown mice: A mouse model for AEC syndrome.

Am J Med Genet A. 2009-9

[7]
Craniofacial and anthropometric phenotype in ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (Hay-Wells syndrome) in a cohort of 17 patients.

Am J Med Genet A. 2009-9

[8]
Clinical lessons learned from the International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome.

Am J Med Genet A. 2009-9

[9]
TAp63 prevents premature aging by promoting adult stem cell maintenance.

Cell Stem Cell. 2009-7-2

[10]
p63 directly induces expression of Alox12, a regulator of epidermal barrier formation.

Exp Dermatol. 2009-12

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