Verdier-Taillefer M H, Zuber M, Lyon-Caen O, Clanet M, Gout O, Louis C, Alpérovitch A
INSERM U 169, Villejuif, France.
Eur Neurol. 1991;31(2):117-9. doi: 10.1159/000116658.
The interobserver variability of the expanded disability status scale (EDSS) was studied in 59 patients with multiple sclerosis (MS). Interrater agreement was measured by the kappa coefficient. Agreement was low in patients with mild disability (EDSS less than 5); it was higher in patients with EDSS equal to or greater than 5. The difference between ratings of 2 independent examiners was equal to at least 1 point in 34% of the MS cases. This variability must be taken into consideration in designing clinical trials in MS.
对59例多发性硬化症（MS）患者的扩展残疾状态量表（EDSS）观察者间变异性进行了研究。评分者间一致性通过kappa系数进行测量。轻度残疾患者（EDSS小于5）的一致性较低；EDSS等于或大于5的患者一致性较高。在34%的MS病例中，两名独立检查者的评分差异至少为1分。在设计MS临床试验时必须考虑到这种变异性。
