新霉素、苯二氮䓬衍生物及酮康唑对胆固醇吸收的抑制作用
Inhibition of cholesterol absorption by neomycin, benzodiazepine derivatives and ketoconazole.
作者信息
Kesäniemi Y A, Miettinen T A
机构信息
Department of Internal Medicine, University of Oulu, Finland.
出版信息
Eur J Clin Pharmacol. 1991;40 Suppl 1:S65-7.
Neomycin and a benzodiazepine derivative (RO16-0521) inhibit similarly cholesterol absorption in man but the serum cholesterol level is reduced only by neomycin. Reason(s) for the difference are unknown. Ketoconazole inhibits 14 alpha-demethylation of lanosterol so that cholesterol synthesis is reduced. The agent inhibits also cholesterol absorption. The serum cholesterol level is reduced by about 20%, the lowering being potentiated by a simultaneous cholestyramine treatment.
新霉素和一种苯二氮䓬衍生物（RO16 - 0521）对人体胆固醇吸收的抑制作用相似，但只有新霉素能降低血清胆固醇水平。造成这种差异的原因尚不清楚。酮康唑抑制羊毛甾醇的14α - 去甲基化，从而减少胆固醇合成。该药物也抑制胆固醇吸收。血清胆固醇水平降低约20%，同时使用考来烯胺治疗可增强这种降低作用。
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