Tilvis R S, Miettinen T A
Am J Clin Nutr. 1986 Jan;43(1):92-7. doi: 10.1093/ajcn/43.1.92.
beta-Sitosterol and campesterol were measured in serum lipoproteins of 17 subjects from two families. The serum levels of the two phytosterols were closely correlated with each other (r = 0.974), less consistently with serum cholesterol (r = 0.489), and not at all with serum triglycerides. As compared to cholesterol, serum free and esterified phytosterols tended to be accumulated in HDL where the phytosterol/cholesterol ratios were almost 40% higher than in VLDL and LDL. The serum phytosterol concentrations, the phytosterol/cholesterol ratios, especially in VLDL and LDL, and the fractional absorption of cholesterol were higher in women than in men. The levels of the phytosterols in whole serum and in each lipoprotein were significantly correlated with the percentage absorption of dietary cholesterol but were independent of the amount of dietary cholesterol and plant sterols. Our findings suggest that, in general, serum levels of noncholesterol sterols are effectively determined by the absorption which in turn is proportionate to the fractional absorption of cholesterol.
对来自两个家族的17名受试者的血清脂蛋白中的β-谷甾醇和菜油甾醇进行了测定。两种植物甾醇的血清水平彼此密切相关（r = 0.974），与血清胆固醇的相关性较差（r = 0.489），与血清甘油三酯则完全无关。与胆固醇相比，血清游离和酯化植物甾醇倾向于在高密度脂蛋白（HDL）中蓄积，其中植物甾醇/胆固醇比值比极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）中的几乎高40%。女性的血清植物甾醇浓度、植物甾醇/胆固醇比值，尤其是在VLDL和LDL中的比值以及胆固醇的分数吸收率均高于男性。全血清和每种脂蛋白中的植物甾醇水平与膳食胆固醇的吸收百分比显著相关，但与膳食胆固醇和植物甾醇的量无关。我们的研究结果表明，一般来说，非胆固醇甾醇的血清水平由吸收有效决定，而吸收又与胆固醇的分数吸收率成比例。
