Nields H M, Snider G L, Christensen T G
Mallory Institute of Pathology, Boston University School of Medicine, Massachusetts 02118.
Eur Respir J. 1991 Feb;4(2):205-9.
The anti-inflammatory drug flurbiprofen speeds the repair of cigarette smoke-induced bronchial secretory cell metaplasia (SCM) in rats. We tested whether flurbiprofen would prevent or mitigate the development of elastase-induced bronchial SCM in hamsters. Twice daily injections of flurbiprofen (4 or 6 mg.kg-1.day-1) were begun immediately after intertracheal instillation of porcine pancreatic elastase (PPE) or its vehicle, saline. At 3 wks, the bronchi of these animals were compared to those of animals receiving PPE or saline. PPE-treated hamsters, with or without flurbiprofen, developed moderate to severe SCM. Control hamsters had normal airways. Flurbiprofen had no effect on the neutrophilic pulmonary infiltrate seen 2 h after PPE instillation. We conclude that the development of elastase-induced SCM in hamsters is not affected by a flurbiprofen regimen begun directly after elastase instillation. The pathogenesis of this lesion may involve factors which are insensitive to flurbiprofen or which trigger the lesion immediately upon exposure to the enzyme.
抗炎药物氟比洛芬可加速大鼠香烟烟雾诱导的支气管分泌细胞化生（SCM）的修复。我们测试了氟比洛芬是否能预防或减轻仓鼠中弹性蛋白酶诱导的支气管SCM的发展。在气管内滴注猪胰弹性蛋白酶（PPE）或其赋形剂生理盐水后，立即开始每日两次注射氟比洛芬（4或6mg·kg-1·天-1）。在3周时，将这些动物的支气管与接受PPE或生理盐水的动物的支气管进行比较。接受PPE治疗的仓鼠，无论是否使用氟比洛芬，均出现中度至重度SCM。对照仓鼠气道正常。氟比洛芬对PPE滴注后2小时出现的嗜中性粒细胞肺浸润没有影响。我们得出结论，弹性蛋白酶诱导的仓鼠SCM的发展不受弹性蛋白酶滴注后直接开始的氟比洛芬治疗方案的影响。该病变的发病机制可能涉及对氟比洛芬不敏感或在接触该酶后立即引发病变的因素。
