Prince of Wales Clinical School and Medical Research Institute, University of New South Wales, Randwick, Sydney, Australia.
J Vestib Res. 2009;19(3-4):137-42. doi: 10.3233/VES-2009-0360.
We investigated the effects of bicathodal stochastic galvanic vestibular stimulation (GVS) on body sway in normal subjects and in Parkinson's Disease (PD) patients. Twenty normal subjects and five PD patients were stimulated with four stimulus intensities between 0 and 0.5 mA and sway was measured in two stance conditions (on a compliant surface with either eyes open (EOCS) or closed (ECCS)). Subjects stood facing forward with their feet together on a force platform. Centre of pressure (CoP) displacement over 26 seconds was measured in the anteroposterior (AP) and mediolateral (ML) planes. GVS had no significant overall effect on sway in the normal subjects. In the patients a small (4.5%) significant decrease in sway was seen in the ECCS condition with low intensity (0.1 mA) stimulation (P=0.02). Similar changes were seen in the normal subjects. This work indicates that low intensities of stochastic GVS can reduce sway levels in PD patients for certain stance conditions.
我们研究了双阴极随机电前庭刺激（GVS）对正常受试者和帕金森病（PD）患者身体摆动的影响。20 名正常受试者和 5 名 PD 患者在 0 至 0.5 mA 的四个刺激强度下接受刺激，并在两种站立姿势条件下（睁眼（EOCS）或闭眼（ECCS）时在柔软表面上）测量摆动。受试者双脚并拢面向前站在力台上。在 26 秒内测量前后（AP）和左右（ML）方向上的中心压力（CoP）位移。GVS 对正常受试者的摆动没有显著的整体影响。在患者中，在低强度（0.1 mA）刺激的 ECCS 条件下，摆动幅度出现小的（4.5%）显著降低（P=0.02）。在正常受试者中也观察到类似的变化。这项工作表明，在某些站立姿势条件下，低强度的随机 GVS 可以降低 PD 患者的摆动水平。
