双核镍-Schiff 碱配合物促进的β-酮酯与甲醛的直接不对称催化Aldol 反应。
Direct catalytic asymmetric aldol reaction of beta-keto esters with formaldehyde promoted by a dinuclear Ni2-Schiff base complex.
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Chem Commun (Camb). 2009 Sep 14(34):5138-40. doi: 10.1039/b912380f. Epub 2009 Jul 24.
DOI:10.1039/b912380f
PMID:20448972
Abstract
A homodinuclear Ni(2)-Schiff base 1 complex (0.1-1 mol%) promoted the direct catalytic asymmetric aldol reaction of beta-keto esters with formaldehyde, giving hydroxymethylated adducts in 94-66% ee.
摘要
一种双核镍（II）-席夫碱 1 配合物（0.1-1 摩尔%）促进了β-酮酯与甲醛的直接催化不对称羟醛缩合反应，得到了羟甲基化加合物，ee 值为 94-66%。
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