一种用于催化β-酮酯与炔酮的不对称1,4-加成反应的稳定同双核双钴（III）-席夫碱配合物。
A stable homodinuclear biscobalt(III)-Schiff base complex for catalytic asymmetric 1,4-addition reactions of beta-keto esters to alkynones.
作者信息
Chen Zhihua, Furutachi Makoto, Kato Yuko, Matsunaga Shigeki, Shibasaki Masakatsu
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Angew Chem Int Ed Engl. 2009;48(12):2218-20. doi: 10.1002/anie.200805967.
Two metal cooperation: A homodinuclear Co(2)-Schiff base complex Co(2)(OAc)(2)-1 promoted the asymmetric 1,4-addition of beta-keto esters to alkynones under solvent-free conditions in air (see scheme). The reactions proceeded without air or moisture sensitivity in high yields and with high enantioselectivities (99-91% ee) at room temperature under highly concentrated conditions (neat-20 M) with 0.1-2.5 mol % catalyst loading.
双金属协同作用
一种同双核钴（II）席夫碱配合物Co₂(OAc)₂ - 1在无溶剂条件下于空气中促进了β - 酮酯对炔酮的不对称1,4 - 加成反应（见反应式）。在室温下，于高浓度条件（纯物质 - 20 M）且催化剂负载量为0.1 - 2.5 mol%时，反应无需对空气或湿气敏感，就能以高收率和高对映选择性（对映体过量值为99 - 91%）进行。
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