用于抗肿瘤药物的钌-芳烃配合物的设计

Design of Ru-arene Complexes for Antitumor Drugs.

作者信息

Su Wei, Li Yuchun, Li Peiyuan

机构信息

Department of Chemistry, Guangxi Teachers Education University, Nanning. China.

College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000. China.

出版信息

Mini Rev Med Chem. 2018;18(2):184-193. doi: 10.2174/1389557517666170510113453.

DOI:10.2174/1389557517666170510113453

PMID:28494728

Abstract

Recently, a number of promising ruthenium complexes have been investigated as anticancer drugs. Ru-arene complexes with [(η6-arene)Ru(X)(Y)(Z)] type, which exhibit a great structural variety, offer much potential in drug design. In this review we provide an overview of the progress in the field of arene ruthenium chemistry. We focus our attention particularly on the molecular structures and the anticancer applications of the Ru-arene complexes. Recent developments in the chemistry of arene ruthenium complexes will provide information for the investigation of novel anticancer organometallic drugs.

摘要

最近，一些有前景的钌配合物作为抗癌药物受到了研究。具有[(η6-芳烃)Ru(X)(Y)(Z)]类型的钌-芳烃配合物结构多样，在药物设计方面具有很大潜力。在本综述中，我们概述了芳烃钌化学领域的进展。我们特别关注钌-芳烃配合物的分子结构和抗癌应用。芳烃钌配合物化学的最新进展将为新型抗癌有机金属药物的研究提供信息。