Zn(OTf)(2)催化胺与碳二亚胺的加成反应：胍的高效合成和 Zn-N 酰胺物种的意外形成。
Zn(OTf)(2)-catalyzed addition of amines to carbodiimides: efficient synthesis of guanidines and unpredicted formation of Zn-N amido species.
机构信息
Beijing National Laboratory for Molecular Sciences (BNLMS), and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
出版信息
Org Biomol Chem. 2010 Apr 21;8(8):1816-20. doi: 10.1039/b923249b.
DOI:10.1039/b923249b
PMID:20449484
Abstract
Zn(OTf)(2) acts as an excellent catalyst precursor for addition of various amine N-H bonds to carbodiimides under an atmosphere of air, offering a convenient synthesis of substituted guanidines with high functional-group tolerance. A Zn-N amido species is shown to act as the active species.
摘要
Zn(OTf)(2) 在空气氛围中作为一种优秀的催化剂前体，用于各种胺 N-H 键与碳二亚胺的加成反应，提供了一种具有高官能团容忍度的取代胍的方便合成方法。研究表明，Zn-N 酰胺物种是活性物种。
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