Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.
Org Lett. 2013 Nov 1;15(21):5420-3. doi: 10.1021/ol402377y. Epub 2013 Oct 22.
A new approach to the synthesis of substituted 5-membered cyclic guanidines is described. Palladium-catalyzed alkene carboamination reactions between acyclic N-allyl guanidines and aryl or alkenyl halides provide these products in good yield. This method allows access to a number of different cyclic guanidine derivatives in only two steps from readily available allylic amines.
介绍了一种合成取代的 5 元环胍的新方法。非环 N-烯丙基胍和芳基或烯基卤化物之间的钯催化烯烃碳酰胺化反应以良好的收率提供这些产物。该方法允许从易得的烯丙基胺仅通过两步反应获得许多不同的环状胍衍生物。