Wang Jiabo, Zhang Xueru, Xiao Xiaohe, Chu Xiaohui, Zhou Canping, Jin Cheng, Yan Dan
China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China.
Zhongguo Zhong Yao Za Zhi. 2010 Feb;35(4):470-6.
The differences of 34 rhubarb samples collected on the market and at producing area were investigated by chemical analysis on the contents of anthraquinones and chromatographic fingerprints, in order to assess the rationality of the commercial specification of rhubarb. The results indicated that the commercial specification of rhubarb was not correlated to the contents of anthraquinones as well as the price. The chromatographic fingerprints of rhubarb samples from different producing area were dissimilar, while the commercial specifications were difficult to be separated. Generally, the rhubarb samples produced in famous-region contained more anthraquinones. This demonstrated rationality on the traditional records of the famous-region of rhubarb from a chemical view. In this study, it was firstly reported that rhubarb could be categorized into two types, chrysophanol-type and rhein-type, based on the proportion of the two constituents in the total anthraquinones after acid hydrohysis. It was found that the rhubarb samples of rhein-type were mostly produced in famous-regions, such as Qinghai, Xizang, West Sichuan and Gansu. The literatures reported that rhein was superior to chrysophanol at many pharmacological effects and pharmacokinetic properties. Hence, we primarily considered that rhein-type rhubarb might be high-quality. These results were helpful to improve the commercial specification of rhubarb from a view of chemical information.
通过对34份市售及产地大黄样品的蒽醌类成分含量及色谱指纹图谱进行化学分析，考察其差异，以评价大黄现行商品规格的合理性。结果表明，大黄的商品规格与蒽醌类成分含量及价格均无相关性。不同产地大黄样品的色谱指纹图谱不同，但商品规格却难以区分。一般来说，道地产区的大黄样品蒽醌类成分含量较高。从化学角度证明了大黄道地产区传统记载的合理性。本研究首次报道，根据大黄酸水解后两种成分在总蒽醌中的比例，大黄可分为大黄酚型和大黄酸型两类。发现大黄酸型大黄样品大多产自青海、西藏、川西、甘肃等道地产区。文献报道，大黄酸在许多药理作用和药代动力学性质方面优于大黄酚。因此，我们初步认为大黄酸型大黄可能为优质品。这些结果有助于从化学信息角度完善大黄的商品规格。
