进行性多灶性白质脑病的影像学表现。
Imaging manifestations of progressive multifocal leukoencephalopathy.
机构信息
Division of Neuroradiology, Department of Diagnostic Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Clin Radiol. 2010 Jun;65(6):431-9. doi: 10.1016/j.crad.2010.03.001.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of JC virus in immunosuppressed patients. The diagnosis is usually suggested on imaging and confirmed by cerebrospinal fluid polymerase chain reaction (PCR) for JC virus DNA. In this article, we review the imaging manifestations of PML on computed tomography (CT), magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), MR spectroscopy, single photon-emission computed tomography (SPECT) and positron-emission tomography (PET), and outline the role of imaging in follow-up and prognostication.
进行性多灶性白质脑病（PML）是一种脱髓鞘疾病，由免疫抑制患者 JC 病毒的再激活引起。该诊断通常基于影像学检查提出，并通过脑脊液聚合酶链反应（PCR）检测 JC 病毒 DNA 得到确认。本文回顾了 PML 在计算机断层扫描（CT）、磁共振成像（MRI）、弥散加权成像（DWI）、弥散张量成像（DTI）、磁共振波谱、单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）上的影像学表现，并概述了影像学在随访和预后中的作用。
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