Lei Ting, Deng Ai, Li Lianchi, Wang Ming, Wu Dongbo, Zhou Taoyou
Center of Infectious Diseases, West China Hospital Sichuan University Chengdu China.
Department of Critical Care Medicine, West China Hospital Sichuan University Chengdu China.
Clin Case Rep. 2023 Aug 8;11(8):e7784. doi: 10.1002/ccr3.7784. eCollection 2023 Aug.
Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection of the brain caused by reactivation of the JC virus, which can lead to a lytic infection of oligodendrocytes. We report a patient with HIV who developed PML.
Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection of the brain caused by reactivation of the John Cunningham virus (JCV), which can lead to a lytic infection of oligodendrocytes. Herein, we report the case of a patient with HIV who developed PML that presented as a progressive disturbance of consciousness and movement. The patient's clinical symptoms progressively deteriorated, and positive JC viral DNA in his cerebrospinal fluid (CSF) helped us diagnose him with PML. Magnetic resonance imaging (MRI) showed multiple asymmetric subcortical and deep white-matter lesions. Although we administered immunoreconstructive therapy, the patient's condition gradually worsened. Therefore, we suggest that PML should be considered if such lesions are found in MRIs of HIV patients.
进行性多灶性白质脑病（PML）是由JC病毒重新激活引起的一种罕见的脑部机会性感染，可导致少突胶质细胞的溶解性感染。我们报告了一名感染HIV且发生PML的患者。
进行性多灶性白质脑病（PML）是由约翰·坎宁安病毒（JCV）重新激活引起的一种罕见的脑部机会性感染，可导致少突胶质细胞的溶解性感染。在此，我们报告一例感染HIV且发生PML的患者，其表现为进行性意识和运动障碍。患者的临床症状逐渐恶化，其脑脊液（CSF）中JC病毒DNA阳性有助于我们诊断其患有PML。磁共振成像（MRI）显示多个不对称的皮质下和深部白质病变。尽管我们给予了免疫重建治疗，但患者的病情仍逐渐恶化。因此，我们建议，如果在HIV患者的MRI中发现此类病变，应考虑PML。
