肥胖和非肥胖阻塞性睡眠呼吸暂停的心血管后果。
Cardiovascular consequences of obese and nonobese obstructive sleep apnea.
机构信息
Division of Pulmonary, Sleep and Critical Care Medicine, Center for Sleep Medicine, Mayo Clinic, 200 First Street South West, Rochester, MN 55901, USA.
出版信息
Med Clin North Am. 2010 May;94(3):465-78. doi: 10.1016/j.mcna.2010.02.003.
Abstract
Current evidence suggests a role for obstructive sleep apnea (OSA) in the development of cardiovascular disorders. However, obesity is an active confounder in this relationship. OSA and obesity share similar pathophysiologic mechanisms potentially leading to cardiovascular disorders. Presence of OSA in obese patients may further contribute to adverse cardiovascular outcomes when compared with each condition in isolation. In this review the authors explore the complex relationship between OSA and obesity (and nonobese subjects) in the development of cardiovascular disorders.
摘要
目前的证据表明，阻塞性睡眠呼吸暂停（OSA）在心血管疾病的发展中起作用。然而，肥胖是这种关系中的一个活跃混杂因素。OSA 和肥胖具有相似的病理生理机制，可能导致心血管疾病。与每种单独的情况相比，肥胖患者中存在 OSA 可能会进一步导致不良心血管结局。在这篇综述中，作者探讨了 OSA 和肥胖（以及非肥胖患者）在心血管疾病发展中的复杂关系。
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2
A new model of chronic intermittent hypoxia in humans: effect on ventilation, sleep, and blood pressure.
J Appl Physiol (1985). 2009 Jul;107(1):17-24. doi: 10.1152/japplphysiol.91165.2008. Epub 2009 Feb 19.
3
Heavy snoring as a cause of carotid artery atherosclerosis.
Sleep. 2008 Sep;31(9):1207-13.
4
Sleep-disordered breathing and cardiovascular disease: an outcome-based definition of hypopneas.
Am J Respir Crit Care Med. 2008 May 15;177(10):1150-5. doi: 10.1164/rccm.200712-1884OC. Epub 2008 Feb 14.
5
Atrial fibrillation and obesity--results of a meta-analysis.
Am Heart J. 2008 Feb;155(2):310-5. doi: 10.1016/j.ahj.2007.10.004. Epub 2007 Dec 19.
6
Disparate effects of left ventricular geometry and obesity on mortality in patients with preserved left ventricular ejection fraction.
Am J Cardiol. 2007 Nov 1;100(9):1460-4. doi: 10.1016/j.amjcard.2007.06.040. Epub 2007 Aug 27.
7
Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study.
Circulation. 2007 Jul 3;116(1):39-48. doi: 10.1161/CIRCULATIONAHA.106.675355. Epub 2007 Jun 18.
8
Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea.
Hypertension. 2007 Aug;50(2):417-23. doi: 10.1161/HYPERTENSIONAHA.106.085175. Epub 2007 Jun 4.
9
Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea.
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10
Auto-titrating continuous positive airway pressure therapy in patients with chronic heart failure and obstructive sleep apnoea: a randomized placebo-controlled trial.
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