Wolk R, Somers V K
Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55902, USA.
Diabetes Obes Metab. 2006 May;8(3):250-60. doi: 10.1111/j.1463-1326.2005.00508.x.
Obesity and obstructive sleep apnea (OSA) often coexist. OSA has been linked to cardiovascular disease. Thus, OSA may contribute to the cardiovascular consequences of obesity. In this review, we explore clinical and pathophysiological interactions between obesity, cardiovascular disease and OSA. We discuss the mechanisms whereby OSA may contribute to hypertension, atherosclerosis, insulin resistance and atrial fibrillation associated with obesity, and emphasize the potential implications for understanding why only a subgroup of obese patients develop cardiovascular disease. Identification of the OSA-dependent and OSA-independent pathways in the cardiovascular pathophysiology of obesity may hold clinical and therapeutic promise.
肥胖与阻塞性睡眠呼吸暂停（OSA）常常并存。OSA已被证明与心血管疾病有关。因此，OSA可能是肥胖导致心血管疾病的一个原因。在这篇综述中，我们探讨了肥胖、心血管疾病和OSA之间的临床及病理生理相互作用。我们讨论了OSA可能导致与肥胖相关的高血压、动脉粥样硬化、胰岛素抵抗和心房颤动的机制，并强调了这对于理解为何只有一部分肥胖患者会发生心血管疾病的潜在意义。确定肥胖心血管病理生理学中OSA依赖和OSA非依赖途径可能具有临床和治疗前景。
