生长分化因子 9 的 G546A 多态性与卵巢储备功能降低的妇女卵巢刺激不良结局有关。
G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve.
机构信息
Department of Reproductive Endocrinology, Zhejiang Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
出版信息
Fertil Steril. 2010 Nov;94(6):2490-2. doi: 10.1016/j.fertnstert.2010.03.070. Epub 2010 May 7.
The growth differential factor-9 (GDF-9) gene, an oocyte-specific factor, was screened in 106 Chinese women with diminished ovarian reserve (DOR), and three single-nucleotide polymorphisms, c.G169A, c.C447T and c.G546A, were detected. We found GDF-9 c.G546A, but not c.G169A or c.C447T, to be correlated with the poor ovarian stimulation and in vitro fertilization outcomes in women with DOR.
生长分化因子 9（GDF-9）基因是一种卵母细胞特异性因子，我们对 106 例卵巢储备功能减退（DOR）的中国女性进行了筛选，检测到三个单核苷酸多态性，c.G169A、c.C447T 和 c.G546A。我们发现 GDF-9 c.G546A 与 DOR 患者卵巢刺激和体外受精结局不良相关，而 c.G169A 或 c.C447T 则没有相关性。
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