Orthopaedic Department, Ludwig-Maximilians-University, 81377 Munich, Germany.
J Biomech. 2010 Aug 10;43(11):2065-9. doi: 10.1016/j.jbiomech.2010.04.009. Epub 2010 May 6.
There is a persisting need for effective therapies of femoral head necrosis, a common bone disease. Promising clinical results have been stated for the treatment with extracorporeal shock waves (ESW). However, the effective remaining pressure in the target region inside the femoral head has never been determined. Aim of this study was to investigate whether ESW are able to propagate through bone without an excessive loss of pressure. The remaining ESW pressure generated by an electromagnetic device after passing a certain intraosseous distance within the femoral head was measured. Standardized holes were drilled in porcine femora and the absorption in relation to reference measurements in degassed water was determined. The results showed continuous attenuation of shock waves in bone. After a clinical relevant intraosseous distance of 10 mm an ESW pressure of approximately 50% remained. In conclusion, ESW have the potential to reach necrotic regions with therapeutic pressure levels and to effectively treat femoral head necrosis.
目前，临床上仍需要有效的方法来治疗股骨头坏死这一常见的骨骼疾病。体外冲击波疗法（ESW）在临床治疗中显示出了良好的效果。然而，股骨头内目标区域的有效剩余压力从未被确定过。本研究旨在探讨 ESW 是否能够在不造成压力过大损失的情况下在骨骼中传播。研究人员使用电磁装置在猪股骨中进行了特定的骨内距离后，测量了产生的剩余 ESW 压力。通过在猪股骨上钻孔，并与去气水中的参考测量值进行比较，确定了压力的吸收情况。结果表明，冲击波在骨骼中会连续衰减。在临床相关的 10mm 骨内距离后，ESW 压力约为 50%。总之，ESW 有潜力到达具有治疗压力水平的坏死区域，并有效地治疗股骨头坏死。
