Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
J Am Soc Echocardiogr. 2010 Oct;23(10):1113.e5-7. doi: 10.1016/j.echo.2010.03.011. Epub 2010 May 7.
A 58-year-old man with a remote history of diffuse large B-cell lymphoma (DLBCL), status post chemotherapy, radiation, and peripheral blood stem cell transplantation, presented with splenic nodular sclerosis classical Hodgkin lymphoma. He was found to have aortic and mitral valve mass lesions. The mitral valve mass showed typical histologic and immunophenotypic features of nodular sclerosis classical Hodgkin lymphoma, whereas the aortic valve mass and aortic mitral curtain tissue showed DLBCL with necrosis. Both tumors were Epstein-Barr virus positive and were clonally related; however, they were not related to his DLBCL from 14 years prior. This is the first case report of a patient with a composite lymphoma affecting two cardiac valves.
一位 58 岁男性，有弥漫性大 B 细胞淋巴瘤（DLBCL）的既往病史，曾接受过化疗、放疗和外周血干细胞移植，现因脾脏结节性硬化型经典霍奇金淋巴瘤就诊。他被发现主动脉瓣和二尖瓣有肿块病变。二尖瓣肿块显示出结节性硬化型经典霍奇金淋巴瘤的典型组织学和免疫表型特征，而主动脉瓣肿块和主动脉二尖瓣幕组织则显示出弥漫性大 B 细胞淋巴瘤伴坏死。两个肿瘤均为 EBV 阳性且克隆相关；然而，它们与他 14 年前的 DLBCL 无关。这是首例累及两个心瓣的复合性淋巴瘤患者的病例报告。
