γδT 细胞与 αβT 细胞谱系定向紊乱。
Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment.
机构信息
Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, S3-137, Worcester, MA 01655, USA.
出版信息
Semin Immunol. 2010 Aug;22(4):222-7. doi: 10.1016/j.smim.2010.04.003. Epub 2010 May 6.
Abstract
The mechanism of T cell precursor commitment to the gammadelta or alphabeta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal.
摘要
T 细胞前体向 gammadelta 或 alphabeta T 细胞谱系的定向机制尚不清楚。虽然基于 TCR 转基因模型，TCR 信号强度已成为谱系定向的关键因素，但整个 TCR 库可能不具有相同的辨别力。TCR 作为谱系决定因素的一个制衡因素是前体中基因表达预先存在的异质性，这表明单个前体不太可能对给定的指示信号做出均匀的反应。
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