Department of Microbiology & Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Semin Immunol. 2010 Aug;22(4):247-51. doi: 10.1016/j.smim.2010.04.006. Epub 2010 May 8.
Signaling by the gammadelta T cell receptor (TCR) is required not only for alphabeta/gammadelta lineage commitment but also to activate and elicit effector functions in mature gammadelta T cells. Notably, at both of these stages, the signal delivered by the gammadeltaTCR is more robust than the one delivered by either the preTCR or the alphabetaTCR. Recent studies now provide evidence that signaling by the gammadeltaTCR is also required at other stages during gammadelta T cell development. Remarkably, the strength of the gammadeltaTCR signal also plays a role at these other stages, as evidenced by the findings that genetic manipulation of gammadeltaTCR signal strength affects gammadelta T cell maturation and effector fate. In this review, we discuss how a strong TCR signal is a recurring theme in gammadelta T cell development and activation.
γδ T 细胞受体 (TCR) 的信号不仅对于 αβ/γδ谱系的确定是必需的，而且对于成熟 γδ T 细胞的激活和效应功能的产生也是必需的。值得注意的是，在这两个阶段，γδ TCR 传递的信号比 preTCR 或 αβ TCR 传递的信号都要强。最近的研究现在提供了证据，表明 γδ TCR 的信号在 γδ T 细胞发育的其他阶段也是必需的。值得注意的是，γδ TCR 信号的强度在这些其他阶段也起着作用，这一点可以从遗传操纵 γδ TCR 信号强度影响 γδ T 细胞成熟和效应命运的发现中得到证明。在这篇综述中，我们讨论了强 TCR 信号如何在 γδ T 细胞的发育和激活中是一个反复出现的主题。
