Department of Pharmacology, Bombay College of Pharmacy, Mumbai 400068, Maharashtra, India.
Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2030-6. doi: 10.1016/j.fct.2010.04.048. Epub 2010 May 6.
Cuminum cyminum is widely used as a spice in many countries. The aim of the present study was to investigate the effect of methanolic extract of seeds of C. cyminum (CC) on diabetes, oxidative stress and formation of advanced glycated end products (AGE) and obtain comparison with glibenclamide. In vitro studies indicated that CC inhibited free radicals and AGE formation. Treatment of streptozotocin-diabetic rats with CC and glibenclamide for 28 days caused a reduction in blood glucose, glycosylated hemoglobin, creatinine, blood urea nitrogen and improved serum insulin and glycogen (liver and skeletal muscle) content when compared to diabetic control rats. Significant reduction in renal oxidative stress and AGE was observed with CC when compared to diabetic control and glibenclamide. CC and glibenclamide improved antioxidant status in kidney and pancreas of diabetic rats. Diabetic rats showed increase in rat tail tendon collagen, glycated collagen, collagen linked fluorescence and reduction in pepsin digestion. Treatment with CC significantly improved these parameters when compared to diabetic control and glibenclamide group. Though the antidiabetic effect of CC was comparable to glibenclamide it had better effect in controlling oxidative stress and inhibiting the AGE formation, which are implicated in the pathogenesis of diabetic microvascular complications.
孜然芹被广泛用作许多国家的香料。本研究的目的是研究孜然芹（CC）种子的甲醇提取物对糖尿病、氧化应激和晚期糖基化终产物（AGE）形成的影响，并与格列本脲进行比较。体外研究表明 CC 抑制自由基和 AGE 形成。用 CC 和格列本脲治疗 28 天的链脲佐菌素诱导的糖尿病大鼠与糖尿病对照组大鼠相比，血糖、糖化血红蛋白、肌酐、血尿素氮降低，血清胰岛素和肝糖原（肝脏和骨骼肌）含量增加。与糖尿病对照组和格列本脲相比，CC 可显著降低肾脏的氧化应激和 AGE。CC 和格列本脲可改善糖尿病大鼠肾脏和胰腺的抗氧化状态。糖尿病大鼠的鼠尾腱胶原、糖化胶原、胶原连接荧光增加，胃蛋白酶消化减少。与糖尿病对照组和格列本脲组相比，CC 治疗可显著改善这些参数。虽然 CC 的降血糖作用与格列本脲相当，但它在控制氧化应激和抑制 AGE 形成方面具有更好的效果，这与糖尿病微血管并发症的发病机制有关。
