Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
Comp Biochem Physiol A Mol Integr Physiol. 2010 Sep;157(1):63-7. doi: 10.1016/j.cbpa.2010.04.020. Epub 2010 May 6.
Neuromedin S (NMS) is recognized as an anorexigenic peptide in the brain of mammals. In chicks (Gallus gallus), however, the effect of NMS has not been investigated. Therefore, the purpose of the present study was to investigate whether intracerebroventricular (ICV) injection of NMS affected feeding and drinking behavior in chicks. The injection of NMS (0.01-1 nmol) significantly decreased food intake under both ad libitum and food deprivation-induced feeding conditions. However, NMS did not affect water deprivation-induced drinking behavior. ICV injection of NMS stimulated voluntary locomotion and wing-flapping behavior. In addition, we found that those effects of NMS might be related to the hypothalamus-pituitary-adrenal axis because ICV injection of NMS stimulated corticosterone release. The present study suggests that central NMS functions an anorexigenic factor in chicks.
神经调节素 S（NMS）在哺乳动物的大脑中被认为是一种厌食性肽。然而，在小鸡（Gallus gallus）中，NMS 的作用尚未得到研究。因此，本研究的目的是探讨脑室注射 NMS 是否会影响小鸡的摄食和饮水行为。NMS（0.01-1 纳摩尔）的注射显著减少了自由摄食和饥饿诱导摄食条件下的食物摄入。然而，NMS 并不影响水剥夺引起的饮水行为。脑室注射 NMS 刺激了自愿的运动和翅膀拍打行为。此外，我们发现 NMS 的这些作用可能与下丘脑-垂体-肾上腺轴有关，因为脑室注射 NMS 刺激了皮质酮的释放。本研究表明，中枢 NMS 是小鸡体内的一种厌食性因子。
