Shousha Saad, Nakahara Keiko, Sato Miho, Mori Kenji, Miyazato Mikiya, Kangawa Kenji, Murakami Noboru
Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Gakuen-kibanadainishi 1-1, Miyazaki 889-2155, Japan.
Neurosci Lett. 2006 Jan 2;391(3):87-90. doi: 10.1016/j.neulet.2005.08.033. Epub 2005 Sep 12.
Neuromedin S (NMS) was recently isolated from the brains of humans, mice and rats as an endogenous ligand for the orphan G protein-coupled receptors FM-3 and FM-4, which have been identified as neuromedin U (NMU) receptors 1 and 2, respectively. To investigate the role of NMS in avian species, we elucidated the effect of intracerebroventricular (i.c.v.) administration of rat NMS on food intake, body weight, body temperature and gross locomotor activity in adult Japanese quails. NMS significantly decreased food intake (and consequently body weight) in a time-dependent manner during 12-h light period, but increased both body temperature and gross locomotor activity. On the other hand, i.c.v. injection of rat NMU showed the reverse effects of NMS in Japanese quail. These results suggest that NMS may play an important role in regulating food intake and sympathetic nerve activity in the Japanese quail.
神经介素S（NMS）最近从人、小鼠和大鼠的大脑中分离出来，作为孤儿G蛋白偶联受体FM-3和FM-4的内源性配体，这两种受体已分别被鉴定为神经介素U（NMU）受体1和受体2。为了研究NMS在鸟类中的作用，我们阐明了脑室内（i.c.v.）注射大鼠NMS对成年日本鹌鹑食物摄入量、体重、体温和总体运动活动的影响。在12小时光照期内，NMS以时间依赖性方式显著降低食物摄入量（进而降低体重），但同时提高了体温和总体运动活动。另一方面，脑室内注射大鼠NMU在日本鹌鹑中显示出与NMS相反的作用。这些结果表明，NMS可能在调节日本鹌鹑的食物摄入量和交感神经活动中发挥重要作用。
