Division of Public Oral Health, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.
Dent Mater. 2010 Aug;26(8):761-70. doi: 10.1016/j.dental.2010.03.021. Epub 2010 May 7.
To quantitatively determine whether the pulp response to resin-modified glass ionomer cements placed in deep cavities differs from that generated by calcium hydroxide cement.
Five databases were searched for articles up to 31 May 2009.
titles/abstracts relevant to topic; published in English; two-arm longitudinal in vivo trial; containing computable dichotomous datasets for test and control group.
not all entered subjects accounted for at the end of the trial; subjects of both groups not followed up in the same way; trial on animal tissue.
One randomized and five non-randomized control trials, reporting on 1 and 17 datasets, respectively, were accepted. From non-randomized trials, the Relative Risk with 95% Confidence Interval of 13 datasets showed no statistically significant differences (p>0.05) and 4 showed a statistically significant difference between both materials. Meta-analysis of datasets from these trials found no difference between the inflammatory cell response after 30 days (0.87; 95%CI 0.59-1.26; p=0.46); 38% less inflammatory cell response with calcium hydroxide after 60 days (0.62; 95%CI 0.50-0.76; p<0.00001); higher number of intact odontoblasts beneath restored cavities after 381 days (0.56; 95%CI 0.38-0.82; p=0.0008). The results from the randomized control trial (1.40; 95%CI 0.92-2.14; p=0.11) indicated no difference in clinically identifiable pulp symptoms after two years. All trials showed limited internal validity due to selection bias.
No conclusive statement about the superiority of either type of material can yet be made. Further high-quality randomized control trials are needed.
定量确定在深窝洞中放置的树脂改良型玻璃离子水门汀的牙髓反应是否与氢氧化钙水泥产生的反应不同。
截至 2009 年 5 月 31 日，检索了 5 个数据库以获取相关文章。
标题/摘要与主题相关；以英文发表；两臂纵向体内试验；包含测试组和对照组可计算的二分数据集。
试验结束时未计算所有纳入对象；两组对象未以相同方式随访；动物组织试验。
接受了一项随机和五项非随机对照试验，分别报告了 1 项和 17 项数据集。非随机试验中，13 项数据集的相对风险（RR）及其 95%置信区间（CI）无统计学差异（p>0.05），4 项数据集显示两种材料之间存在统计学差异。对这些试验的数据集进行荟萃分析发现，在 30 天后炎症细胞反应无差异（0.87；95%CI 0.59-1.26；p=0.46）；60 天后氢氧化钙的炎症细胞反应减少 38%（0.62；95%CI 0.50-0.76；p<0.00001）；381 天后修复窝洞下有更多完整的成牙本质细胞（0.56；95%CI 0.38-0.82；p=0.0008）。随机对照试验的结果（1.40；95%CI 0.92-2.14；p=0.11）表明，两年后在临床上可识别的牙髓症状无差异。所有试验均因选择偏倚而显示出有限的内部有效性。
目前尚不能对任何一种材料的优势做出明确的结论。需要进一步开展高质量的随机对照试验。
