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基于家系的关联研究在韩国人群中发现 AVPR1A 5'侧翼区微卫星与自闭症谱系障碍的关系。

Family-based association study of microsatellites in the 5' flanking region of AVPR1A with autism spectrum disorder in the Korean population.

机构信息

Department of Pharmacology, School of Medicine, Eulji University, Daejon, Republic of Korea.

出版信息

Psychiatry Res. 2010 Jun 30;178(1):199-201. doi: 10.1016/j.psychres.2009.11.007. Epub 2010 May 7.

DOI:10.1016/j.psychres.2009.11.007
PMID:20452058
Abstract

This study evaluated the association between autism spectrum disorders (ASDs) and microsatellites (RS3 and RS1) in the 5' flanking region of AVPR1A in 148 Korean trios comprising children with ASDs. In the transmission equilibrium test and haplotype analysis, we found a statistically significant association between microsatellites and Korean ASDs.

摘要

本研究评估了自闭症谱系障碍（ASD）与 AVPR1A 基因 5'侧翼区微卫星（RS3 和 RS1）之间的关联，该研究纳入了 148 个韩国三核苷酸重复序列，包含了 ASD 患儿。在传递平衡检验和单体型分析中，我们发现微卫星与韩国 ASD 之间存在统计学显著关联。

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