Keno Y, Matsuzawa Y, Tokunaga K, Fujioka S, Kawamoto T, Kobatake T, Tarui S
Second Department of Internal Medicine, Osaka University Medical School, Japan.
Int J Obes. 1991 Mar;15(3):205-11.
We have previously reported that metabolic abnormalities in obese subjects are closely related to intraabdominal fat accumulation. In order to clarify the causal relationship between high sucrose intake and intraabdominal visceral fat accumulation, the effects of a high sucrose diet on mesenteric fat weight, fasting plasma glucose (FPG) and triglyceride (TG) levels were investigated in bilateral ventromedial hypothalamic-lesioned obese rats (VMH) and control rats (control). The mesenteric fat weight (g)/abdominal subcutaneous fat weight (g) (M/S ratio), a parameter of visceral fat accumulation, was significantly higher in a high sucrose diet fed group (HSD group) (VMH 1.94 +/- 0.71, control 1.63 +/- 0.28) than in a lab chow fed group (LC group) (VMH 1.30 +/- 0.31, control 1.27 +/- 0.33) (P less than 0.01). In addition, the fat cell volume of mesenteric fat deposits was significantly greater in the HSD group (VMH 1.17 +/- 0.26 nl, control 0.24 +/- 0.10 nl) than in the LC group (VMH 0.74 +/- 0.27 nl, control 0.14 +/- 0.07 nl) (P less than 0.001), although the fat cell number did not differ among any experimental rat groups. FPG and TG levels were higher in the HSD group than in the LC group in VMH-lesioned rats, and a significant correlation was observed between mesenteric fat volume and FPG levels (VMH r = 0.58, P less than 0.05; control r = 0.50, P less than 0.05) as well as between mesenteric fat volume and TG levels (VMH r = 0.49, P less than 0.05; control r = 0.56, P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
我们之前曾报道过，肥胖受试者的代谢异常与腹内脂肪堆积密切相关。为了阐明高蔗糖摄入与腹内内脏脂肪堆积之间的因果关系，我们研究了高蔗糖饮食对双侧腹内侧下丘脑损伤的肥胖大鼠（VMH）和对照大鼠（对照组）肠系膜脂肪重量、空腹血糖（FPG）和甘油三酯（TG）水平的影响。作为内脏脂肪堆积参数的肠系膜脂肪重量（克）/腹部皮下脂肪重量（克）（M/S比值），在高蔗糖饮食喂养组（HSD组）（VMH为1.94±0.71，对照组为1.63±0.28）显著高于实验室普通饲料喂养组（LC组）（VMH为1.30±0.31），对照组为1.27±0.33）（P<0.01）。此外，HSD组（VMH为1.17±0.26 nl，对照组为0.24±0.10 nl）肠系膜脂肪沉积物的脂肪细胞体积显著大于LC组（VMH为0.74±0.27 nl，对照组为0.14±0.07 nl）（P<0.001），尽管任何实验大鼠组之间的脂肪细胞数量没有差异。VMH损伤大鼠的HSD组FPG和TG水平高于LC组，并且观察到肠系膜脂肪体积与FPG水平之间存在显著相关性（VMH r=0.58，P<0.05；对照组r=0.50，P<0.
