EBV 和 KSHV 对 NF-κB 信号的调节。

NF-kappaB signaling modulation by EBV and KSHV.

机构信息

Department of Pathology, Botucatu School of Medicine, Sao Paulo State University (UNESP), Rubiao Junior, s/n - Botucatu, SP 18618-000, Brazil.

出版信息

Trends Microbiol. 2010 Jun;18(6):248-57. doi: 10.1016/j.tim.2010.04.001. Epub 2010 May 6.

DOI:10.1016/j.tim.2010.04.001

PMID:20452220

Abstract

The nuclear factor (NF)-kappaB signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gammaherpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappaB signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappaB modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.

摘要

核因子 (NF)-kappaB 信号通路对免疫系统功能至关重要。毫不奇怪，病原微生物已经开发出了颠覆它的策略。其中两个例子是 Epstein-Barr 病毒 (EBV) 和卡波济肉瘤疱疹病毒 (KSHV)，它们是致瘤性的γ疱疹病毒，在其人类宿主中建立终身潜伏感染。EBV 和 KSHV 对 NF-kappaB 信号的调节不仅对病毒感染很重要，而且有助于恶性肿瘤的发展。这篇综述探讨了 EBV 和 KSHV 对 NF-kappaB 调节的最新认识，重点关注病毒生物学与人类致癌之间的联系。