Latanova Anastasia, Starodubova Elizaveta, Karpov Vadim
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Viruses. 2022 Aug 18;14(8):1808. doi: 10.3390/v14081808.
Members of the family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans. nonstructural proteins, apart from their canonical roles in viral replication, have noncanonical functions strongly affecting antiviral innate immunity. Among these functions, antagonism of type I IFN is the most investigated; meanwhile, more data are accumulated on their role in the other pathways of innate response. This review systematizes the last known data on the role of nonstructural proteins in molecular mechanisms of triggering inflammation, with an emphasis on their interactions with TLRs and RLRs, interference with NF-κB and cGAS-STING signaling, and activation of inflammasomes.
该病毒家族的成员正在对全球人类健康构成重大威胁。许多黄病毒能够在人类中引发严重炎症。非结构蛋白除了在病毒复制中具有典型作用外，还具有强烈影响抗病毒先天免疫的非典型功能。在这些功能中，对I型干扰素的拮抗作用研究得最多；与此同时，关于它们在先天反应的其他途径中的作用也积累了更多数据。本综述系统整理了关于非结构蛋白在引发炎症的分子机制中作用的最新已知数据，重点关注它们与Toll样受体（TLR）和视黄酸诱导基因I样受体（RLR）的相互作用、对核因子κB（NF-κB）和环鸟苷酸-腺苷酸合成酶-干扰素基因刺激因子（cGAS-STING）信号传导的干扰以及炎性小体的激活。
